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We do not know the exact cause
of UCD

However, many doctors and scientists
believe it is caused by changes in the
immune system.

Many patients with UCD can be cured

If successfully treated, UCD does not significantly influence life-expectancy. Over 90% of patients are alive 5 years after diagnosis.1

What are the

signs and symptoms

of UCD?

If you have UCD, you may not notice any symptoms. However, if symptoms do occur, they usually depend on where in your body the affected lymph nodes are. As the lymph nodes get larger, they can press on other parts of the body and cause symptoms.

Common

symptoms

include:

icon-fullness

A feeling of pressure or fullness in the chest or stomach

icon-difficult-to-breath

Finding it difficult to eat or breathe

icon-weight-loss

Weight loss despite no changes in diet or exercise

Less common

symptoms

include:

icon-fever

Fever
(high temperature)

icon-sweats

Profuse sweating at night

icon-feeling-weak

Feeling weak
(loss of strength)

icon-feeling-sick

Feeling sick

icon-feeling-tired

Feeling tired

Talk to your doctor if you have any of these symptoms, especially if you have experienced them for several days. If you have difficulty breathing, see a doctor as soon as possible.

LIVING WITH iMCD USEFUL RESOURCES
REFERENCES

References

  1. Zhang X, Rao H, Xu X, et al. Clinical characteristics and outcomes of Castleman disease: A multicenter study of 185 Chinese patients. Cancer Sci. 2018; 109(1): 199–206.

Sources:
American Cancer Society: https://www.cancer.org/cancer/castleman-disease (Date Accessed 6 Nov 2023)
Genetic and Rare Diseases Information Centre, Multicentric Castleman disease: https://rarediseases.info.nih.gov/diseases/9644/multicentric-castleman-disease (Date Accessed 6 Nov 2023)
National Organization for Rare Disorders: https://rarediseases.org/rare-diseases/castlemans-disease/ (Date Accessed 6 Nov 2023)

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